Mathematical modeling of histone modifications reveals the formation mechanism and function of bivalent chromatin

Summary: Bivalent chromatin is characterized by occupation of both activating and repressive histone modifications.Here, we develop a mathematical model that involves antagonistic histone modifications H3K4me3 and H3K27me3 to capture the key features of bivalent chromatin.Three necessary conditions for the emergence of bivalent chromatin are identi

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